Updated: Jul 11
Horses improved clinically when this drug was given by nebulization in the following clinical study.
Of 10 Standardbreds and 2 Thoroughbreds in racing condition and with signs of allergies and small airway disease, 6 horses placed on "sodium cromoglycate" nebulization showed clinical improvement. Prior to treatment, signs included coughing, expiratory distress, dyspnea, and submaximal performance of fewer than 2 weeks duration. Bronchoalveolar lavages revealed increased metachromatic cell differential counts. Horses were nebulized with either a sterile isotonic placebo (10ml) or 200mg (10ml) sodium cromoglycate for 5 days. Prior to and within 2 hours of the final treatment, all horses were given a clinical respiratory exam, and a bronchoscopic bronchoalveolar lavage was performed. Histamine quantitation was carried out on metachromatic cells, lavage supernatant, and cell lysate by radioimmunoassay. All horses treated with sodium cromoglycate (Cromolyn Sodium) showed a significant improvement in their clinical respiratory exam and a reduction in metachromatic cell histamine levels. Metachromatic cells, which exhibit metachromasia, may be important in the pathophysiology of small airway disease due to the release of inflammatory mediators and chemoattractants.
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