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Could Oral Interferon-Alpha Boost Your Horse's Immune System?

A healthy immune system is crucial for keeping horses healthy and free from disease. As horse owners, we're always looking for safe and effective ways to support our horses' immune function. One intriguing immunomodulator that has recently gained attention in equine medicine is oral interferon-alpha. In this blog post, we'll explore what the research says so far about using oral interferon-alpha to modulate immune function in horses.

What is Interferon-Alpha?

Interferons are signaling proteins that are naturally produced by the body in response to pathogens like viruses, bacteria, and parasites. There are several types of interferons, including interferon-alpha, interferon-beta, and interferon-gamma. Interferon-alpha is thought to play an important role in innate immune response and may have antiviral, antiproliferative, and immunomodulatory effects.

Interferon-alpha has been studied for potential clinical applications in both human and veterinary medicine. Most research has focused on injectable forms of interferon-alpha, but more recently an oral formulation has become available. Oral delivery allows for easier repeated administration over time.

Research on Oral Interferon-Alpha in Horses

Multiple research studies have looked at the use of oral interferon-alpha in adult horses as a way to boost immune function.

In one study, oral interferon-alpha given for 35 days was found to increase neutrophil function and lymphocyte proliferation in healthy horses. The researchers concluded that oral interferon-alpha could potentially help prevent infections through immuno-stimulant effects. Another study looked at markers of immunity in weanling horses treated with oral interferon-alpha for 35 days. Treated foals were found to have increased interferon-gamma production compared to untreated foals. The researchers suggested oral interferon-alpha could help support the immature immune systems of newly weaned foals.

Researchers have also explored the use of oral interferon-alpha to protect adult horses from infectious disease. A trial on horses experimentally infected with equine herpesvirus-1 found that oral interferon-alpha did not protect against disease, although treatment did decrease cell-associated viremia during the incubation period.

While current research on oral interferon-alpha in horses shows some promising immune effects, more studies are still needed to determine its clinical efficacy and safety. Many questions remain about the optimal treatment regimen that should be used. But oral interferon-alpha's potential as an immunomodulator in horses is an exciting area for future research.


Oral interferon-alpha is an interesting immunomodulatory supplement, though its benefits are still being elucidated. More research is needed, especially clinical trials on its efficacy for protecting horses from infectious diseases like influenza, strangles, and rhodococcus.

Owners interested in trying oral interferon-alpha for immune support should consult their vet and purchase from reputable supplement companies. As with any supplement, proper dosing for the individual horse and monitoring for adverse effects is important. While not a miracle cure, oral interferon-alpha may have potential to give the equine immune system a helpful boost.


Modulating immune function to prevent disease is an appealing concept in equine medicine. While the research is still preliminary, some studies suggest oral interferon-alpha could provide immune-stimulating benefits in adult horses and foals. However, until more clinical trials are completed, the efficacy of oral interferon-alpha remains undetermined. As we learn more, oral interferon-alpha or other immunomodulators might become useful tools for supporting horses' immune health. But for now, owners should weigh the current limited evidence when considering trying these types of supplements. As always, discussing options with your veterinarian is the best way to make informed decisions about your horse's health.

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