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Harnessing the Power of DL-Phenylalanine: A Promising Approach to Controlling Pain in Horses

Updated: Dec 27, 2023

Pain management in horses is of paramount importance to ensure their well-being, performance, and overall quality of life. In recent years, researchers and veterinarians have explored various therapeutic options to effectively control pain in these magnificent animals. One such promising approach involves the use of DL-Phenylalanine, a supplement that has shown potential in alleviating pain and improving the comfort of horses. In this blog post, we will delve into the mechanism of action of DL-Phenylalanine and discuss its recommended dosage for pain management in horses.

Understanding the Mechanism of Action:

DL-Phenylalanine is an amino acid supplement that consists of a combination of two forms of phenylalanine: D-Phenylalanine and L-Phenylalanine. This unique formulation allows DL-Phenylalanine to exert its pain-controlling effects through various mechanisms.

  1. Endorphin Regulation: DL-Phenylalanine enhances the production and release of endorphins, which are natural pain-relieving compounds in the body. By increasing endorphin levels, DL-Phenylalanine can help modulate pain perception and reduce discomfort in horses.

  2. Enzyme Inhibition: D-Phenylalanine, one of the components of DL-Phenylalanine, inhibits the activity of an enzyme called carboxypeptidase A. This enzyme is responsible for breaking down enkephalins, which are neurotransmitters involved in pain regulation. By inhibiting this enzyme, DL-Phenylalanine helps to prolong the effects of enkephalins, thereby reducing pain sensation in horses.

Recommended Dosage for Horses:

Determining the appropriate dosage of DL-Phenylalanine for horses requires careful consideration and consultation with a veterinarian. The dosage can vary depending on the horse's weight, individual response, and the severity of pain being addressed. It is crucial to follow your veterinarian's instructions and use a high-quality DL-Phenylalanine supplement from a reputable source.

Typically, DL-Phenylalanine is available in powder or capsule form. The dosage ranges between 20 to 100 milligrams per kilogram of body weight, given orally once or twice daily. However, it is essential to note that each horse is unique, and the dosage may need to be adjusted based on the specific circumstances and response to treatment. Furthermore, DL-Phenylalanine should always be administered as part of a comprehensive pain management plan, which may include other interventions such as proper hoof care, appropriate exercise, and, if necessary, other pain medications prescribed by your veterinarian.


DL-Phenylalanine holds promise as a valuable tool in the management of pain in horses. By enhancing endorphin release and inhibiting the breakdown of pain-regulating neurotransmitters, DL-Phenylalanine can contribute to reducing pain perception and enhancing the overall well-being of horses. However, it is crucial to remember that DL-Phenylalanine should be used under veterinary guidance, with a carefully tailored dosage for each horse. Always consult with a knowledgeable veterinarian before initiating any pain management regimen to ensure the best possible outcomes for your equine companion.

Subtle Sign of Pain: see the picture below

CLICK HERE to order Dolor (which contains phenylalanine)

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