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Isoxsuprine: The Solution for Sore Feet and Tying Up in Performance Horses

As horse enthusiasts and caretakers, we understand the importance of maintaining the well-being and performance of our equine companions. Horses involved in rigorous activities, such as racing or competitive events, are particularly prone to conditions like sore feet and tying up, which can significantly hinder their performance. Fortunately, veterinary science has made great strides in developing effective treatments, one of which is isoxsuprine. In this blog post, we will explore how isoxsuprine can benefit horses suffering from sore feet and tying up, promoting their overall health and optimizing their performance.

Understanding Sore Feet in Horses

Sore feet in horses can result from various factors, including excessive exercise, improper hoof care, laminitis, or certain health conditions. The discomfort and pain associated with sore feet can limit a horse's mobility, affect its gait, and ultimately hinder its performance. Proper diagnosis and treatment are crucial to ensuring the horse's well-being and recovery.

Isoxsuprine: A Vasodilator for Enhanced Blood Flow

Isoxsuprine, also known by its brand names like Vasodilan, Dilaflex, and Navilox, is a vasodilator that primarily works by relaxing and widening the blood vessels. It belongs to a class of drugs called beta-adrenergic agonists. By promoting vasodilation, isoxsuprine enhances blood flow to various tissues, including the hooves, which can be particularly beneficial for horses suffering from sore feet.

Benefits for Sore Feet

  1. Improved Blood Circulation: Isoxsuprine helps increase blood flow to the horse's hooves, which promotes better oxygenation and nutrient supply. This improved circulation aids in the healing process of damaged tissues, reduces inflammation, and alleviates discomfort.

  2. Pain Relief: By enhancing blood flow and reducing inflammation, isoxsuprine can effectively reduce pain associated with sore feet. Horses administered with isoxsuprine often experience a noticeable improvement in comfort and mobility.

  3. Enhanced Hoof Growth: Isoxsuprine can contribute to the growth and repair of damaged hooves. Improved circulation helps deliver essential nutrients and oxygen to the hooves, facilitating the growth of healthy tissue and encouraging the regeneration of damaged structures.

Tying Up in Performance Horses

Tying up, also known as exertional rhabdomyolysis or azoturia, is a condition characterized by muscle stiffness, pain, and cramping, usually occurring after intense exercise. It can be a result of various factors, including electrolyte imbalances, muscle fatigue, stress, or genetic predisposition. Tying up can significantly impact a performance horse's performance, endurance, and overall well-being. Role of Isoxsuprine in Tying Up

  1. Increased Blood Flow: Similar to its effect on sore feet, isoxsuprine's ability to enhance blood flow can be beneficial for horses prone to tying up. Improved circulation helps flush out metabolic waste products from the muscles, reducing the likelihood of muscle cramping and stiffness.

  2. Muscle Relaxation: Isoxsuprine's vasodilatory effects not only promote blood flow but also induce muscle relaxation. Relaxed muscles are less likely to experience spasms and cramps, which are characteristic symptoms of tying up.

  3. Prevention of Muscle Damage: By optimizing blood flow, isoxsuprine helps deliver essential nutrients and oxygen to the muscles during exercise. This process aids in reducing the risk of muscle damage and the subsequent release of muscle enzymes into the bloodstream, which can occur during tying up.

Consulting with a Veterinarian

It is crucial to consult with a veterinarian before administering any medication, including isoxsuprine, to your horse. A professional evaluation of the horse's condition, along with a thorough examination, will ensure the proper diagnosis and appropriate treatment plan. The veterinarian will consider the horse's overall health, medical history, and any potential contraindications before recommending the use of isoxsuprine.


Isoxsuprine, a vasodilator, can be a valuable tool in the management of sore feet and tying up in performance horses. Its ability to enhance blood flow, reduce inflammation, and promote muscle relaxation provides a holistic approach to improving the well-being and performance of horses. However, it is essential to remember that isoxsuprine should only be used under the guidance and supervision of a veterinarian. By working closely with a professional, you can ensure that your horse receives the appropriate treatment and care it deserves, leading to a happier, healthier, and high-performing equine partner.

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