Omeprazole and Misoprostol Ulcer Paste for Horses: A Complete Guide to Advanced Gastric Ulcer Support

Equine gastric ulcers are a common and costly health issue in performance horses, breeding stock, and horses under stress. Modern veterinary medicine increasingly supports combination ulcer therapy, and one of the most effective approaches is the omeprazole and misoprostol ulcer paste for horses.

This dual-action formulation targets both acid suppression and mucosal protection, offering comprehensive support for horses suffering from Equine Gastric Ulcer Syndrome (EGUS).

What Is Omeprazole and Misoprostol Ulcer Paste?

An omeprazole–misoprostol ulcer paste is a compounded or commercial veterinary formulation designed to support healing of gastric and duodenal ulcers in horses.

Key Components:

Omeprazole – a proton pump inhibitor (PPI) that reduces stomach acid production

Misoprostol – a prostaglandin analog that protects and repairs the stomach lining

Together, they address both the cause and the damage associated with equine ulcers.

How Omeprazole Helps Horses With Ulcers

Omeprazole is widely regarded as the gold standard for equine gastric ulcer treatment.

Benefits of Omeprazole in Horses:

Suppresses excess stomach acid

Promotes healing of squamous gastric ulcers

Helps prevent ulcer recurrence during stress, travel, or training

Improves appetite and performance comfort

Omeprazole is especially effective for squamous ulcers, which are common in performance and racehorses.

Why Misoprostol Is Added to Ulcer Paste

Misoprostol plays a critical role in protecting the glandular stomach lining, an area where ulcers can be more difficult to treat.

Benefits of Misoprostol for Horses:

Increases protective mucus and bicarbonate secretion

Improves blood flow to gastric tissues

Counteracts ulcer damage caused by NSAIDs (such as phenylbutazone)

Supports healing of glandular and pyloric ulcers

Misoprostol is particularly useful in horses with NSAID-induced ulcers or chronic glandular disease.

Advantages of Combination Ulcer Therapy in Horses

Using omeprazole and misoprostol together provides broader and more complete ulcer support than single-drug therapy.

Why Vets Recommend Combination Therapy:

Targets both acid production and mucosal damage

Improves healing outcomes in stubborn or recurring ulcers

Supports horses that fail to respond to omeprazole alone

Beneficial for high-risk horses (performance, breeding, long-term NSAID use)

This approach is increasingly used in sport horses, racehorses, and older horses with complex ulcer histories.

Which Horses Benefit Most From Omeprazole–Misoprostol Paste?

This ulcer paste combination may be recommended for horses that:

Have confirmed gastric or glandular ulcers

Show poor response to omeprazole alone

Are on long-term NSAIDs

Experience frequent ulcer recurrence

Display chronic symptoms such as girthiness, poor appetite, or weight loss

⚠️ Important Safety Note:

Misoprostol must not be used in pregnant mares, as it can cause uterine contractions and abortion. Always consult a veterinarian before use.

Paste Formulation: Why It Matters

Paste delivery is ideal for horses because it:

Allows accurate oral administration

Improves absorption compared to feed-mixed products

Ensures consistent daily dosing

Is practical for barn and travel use

An ulcer paste formulation ensures both medications reach the stomach effectively.

Supporting Ulcer Treatment With Management Changes

While medication is essential, best results come from combining treatment with proper management:

Increase forage and reduce fasting time

Limit grain and high-starch feeds

Provide turnout and stress reduction

Avoid unnecessary NSAID use

Maintain a consistent feeding and exercise schedule

Final Thoughts: A Comprehensive Solution for Equine Ulcers

The omeprazole and misoprostol ulcer paste for horses represents a modern, science-backed approach to equine gastric ulcer management. By combining acid control with mucosal protection, this therapy offers improved healing, comfort, and long-term digestive health.

If your horse shows signs of ulcers or has a history of gastric disease, consult your veterinarian to determine whether combination ulcer therapy is the right solution.

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