Omeprazole/Misoprostol Ulcer Paste for Horses: A Powerful Combo for Equine Gastric Health

Equine gastric ulcers are a widespread issue in performance horses, with studies suggesting that up to 90% of racehorses and 60% of show horses suffer from some degree of ulceration. If your horse shows signs like poor appetite, girthiness, intermittent colic, or behavioral changes, it could be battling Equine Gastric Ulcer Syndrome (EGUS).

One of the most effective treatment approaches gaining attention in recent years is the combination of Omeprazole and Misoprostol in an ulcer paste formulation. Let’s explore why this duo is being hailed as a game-changer in equine ulcer treatment.

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What is Omeprazole/Misoprostol Ulcer Paste?

Omeprazole/Misoprostol ulcer paste is a compounded medication designed to treat and prevent gastric ulcers in horses. This combination brings together two potent agents:

1. Omeprazole

A proton pump inhibitor (PPI) that significantly reduces stomach acid by blocking the acid-producing pumps in the stomach lining. It’s the gold standard for treating glandular and squamous ulcers in horses.

2. Misoprostol

A synthetic prostaglandin E1 analogue that protects the stomach lining, enhances mucosal blood flow, and stimulates mucus and bicarbonate secretion. It also has anti-inflammatory properties, making it especially beneficial in NSAID-induced ulcers.

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Why Combine Omeprazole and Misoprostol?

While Omeprazole alone is highly effective at reducing acid, it does not address mucosal inflammation or damage caused by NSAIDs like Bute or Banamine. That’s where Misoprostol steps in.

Together, Omeprazole and Misoprostol offer a dual-action treatment:

Suppress acid production (Omeprazole)

Protect and heal the mucosal lining (Misoprostol)

This combo is particularly effective for:

Glandular ulcers

NSAID-related gastric damage

Ulcers that don’t fully respond to Omeprazole alone

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Key Benefits of Omeprazole/Misoprostol Ulcer Paste

✅ Enhanced healing rate for complex ulcers

✅ Effective for squamous and glandular ulcers

✅ Protects against NSAID-induced mucosal damage

✅ Convenient paste formulation for easy dosing

✅ Cost-effective when compounded compared to branded treatments

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How to Use the Ulcer Paste

Your veterinarian will determine the exact dosage, but general guidelines include:

Administer once daily, on an empty stomach if possible

Duration: Typically 14–28 days, depending on severity

Follow up with maintenance doses or preventive strategies if your horse remains in heavy training or stress

Always consult your vet before starting treatment, especially for horses with pre-existing conditions, breeding mares, or foals.

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Where to Buy Omeprazole/Misoprostol Paste for Horses

Because it’s a compounded medication, this ulcer paste is available by veterinary prescription through licensed compounding pharmacies. Be sure to choose a reputable source that specializes in equine pharmaceuticals to ensure accurate dosing and quality control.

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Common Signs Your Horse May Need Ulcer Treatment

If you’re not sure whether your horse has ulcers, here are some signs to watch for:

Reluctance to eat or finish grain

Sour attitude, girthiness

Poor body condition despite proper feeding

Mild, recurring colic

Behavioral changes under saddle

Grinding teeth or cribbing

If you observe these symptoms, a gastroscopy (stomach scope) is the gold standard for diagnosis.

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Final Thoughts

The combination of Omeprazole and Misoprostol in a convenient paste form is proving to be one of the most comprehensive and effective treatments for equine gastric ulcers, especially in horses with complicated or recurring ulcer cases.

Whether your horse is a high-performance athlete or a cherished trail companion, supporting gastric health is crucial to overall well-being and performance. Talk to your vet today about whether Omeprazole/Misoprostol ulcer paste is right for your horse.

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