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Optimizing EPM Treatment: The Synergy of DMSO IV and Toltrazuril for Horses

Equine Protozoal Myeloencephalitis (EPM) is a debilitating neurological disease that can affect horses of all breeds and ages. The good news is that modern medicine has provided us with effective treatments like Toltrazuril, which can help horses recover from EPM. However, to maximize the benefits of this treatment and ensure a swift and complete recovery, veterinarians and horse owners have started to explore the use of Dimethyl Sulfoxide (DMSO) intravenous therapy. In this blog, we will delve into the importance of using DMSO IV therapy after treating EPM with Toltrazuril in horses.

Understanding EPM and Toltrazuril

EPM is caused by the protozoan parasite Sarcocystis neurona and can result in a range of neurological symptoms, including muscle weakness, loss of coordination, and even paralysis in severe cases. Toltrazuril, a widely used antiprotozoal medication, is administered to EPM-infected horses to target and eliminate the parasite responsible for the disease. Toltrazuril is known for its effectiveness in managing EPM, helping affected horses recover and regain their normal function.

The Role of DMSO in EPM Treatment

DMSO, or Dimethyl Sulfoxide, is a well-known solvent and delivery vehicle for medications. It is used in various medical applications, including veterinary medicine, to enhance the absorption and effectiveness of drugs. When it comes to EPM treatment, the use of DMSO in conjunction with Toltrazuril can offer several significant advantages:

  1. Enhanced Drug Delivery: DMSO acts as a potent carrier that can facilitate the transport of Toltrazuril into the horse's bloodstream and across biological barriers. This enhanced drug delivery helps ensure that the medication reaches the target site and effectively combats the protozoan parasite causing EPM.

  2. Reduced Inflammation: EPM can cause inflammation in the nervous system, leading to pain and discomfort for affected horses. DMSO has anti-inflammatory properties, which can help alleviate some of these symptoms, making the recovery process more comfortable for the horse.

  3. Neurological Support: The neurological damage caused by EPM can be extensive. DMSO has shown potential in promoting nerve repair and regeneration, which is crucial for horses to regain their normal neurological function.

  4. Improved Blood Flow: DMSO is known to enhance blood flow, which can be particularly beneficial for the affected areas of the nervous system. Improved circulation aids in the removal of waste products and the delivery of essential nutrients to support the healing process.

  5. Rapid Recovery: When DMSO is used in combination with Toltrazuril, it can expedite the recovery process, reducing the time horses spend dealing with the debilitating effects of EPM.


EPM is a challenging condition, but with the right treatment approach, horses can recover and return to their normal, healthy selves. Toltrazuril is a proven EPM treatment, and when combined with DMSO intravenous therapy, its effectiveness is further enhanced. DMSO helps improve drug delivery, reduce inflammation, support the nervous system, and accelerate recovery, ensuring a faster and more complete healing process for horses affected by EPM.

It's crucial to consult with a qualified veterinarian before implementing DMSO IV therapy in conjunction with Toltrazuril treatment, as individual horse needs may vary. With proper care and attention, EPM-affected horses have a better chance at returning to a life free from the debilitating effects of this disease.

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